The program sets its discussion in a classroom and presents the subject in non-medical terms, making it accessible to staff members who are not familiar with medical terminology. Featuring an entertaining fictional host, Professor Farnsworth, the training program identifies the three common bloodborne pathogens and discusses their symptoms. It then traces how these organisms spread and infect people in a variety of ways.

Bloodborne Pathogens In Schools: The Fundamentals covers three major infection-control tools: the Exposure Control Manual, Standard Precautions, and personal protective equipment. It trains school personnel to handle bleeding emergencies safely and shows them what to do if they are exposed to blood.

The program devotes a section to hand hygiene, covering CDC-recommended guidelines, step-by-step hand-washing procedures and the proper use of antiseptic towelettes or alcohol-based sanitizers. It also discusses proper clean-up, good housekeeping, and personal hygiene.